♠AKxxxx
♥AKJ
♦Ax
♣QT
One spade will inevitably receive a forcing 1NT response, meaning I have to jump in hearts to force game.
On the other hand, after 2♣-2♦-2♠-3♦-3♠ it's asking a lot of partner to bid 3NT with a misfit. 2♦ is waiting.
I always regret it when I open these 2♣.

addendum: They are vulnerable. IMPS